10 years of IMO

Last summer we celebrated 10 years of Integrated Mathematical Oncology at the Moffitt Cancer Center. I thought I would use this milestone to take some time to relate how extraordinary this place is.

Big bang vs clonal sweep

The big bang theory of cancer suggests that for many cancers, being early is more important than having fitness-conferring mutations. While the data suggests that this is true in many cases, the reason why some cancers can be characterized as big bang whereas others fit the clonal-sweep paradigm better is not clear. Jack Edwards, a SPARK student, has spent some time thinking about it.

Bone metastasis code on Github

We aim to be as open as possible but often the perfect is the enemy of the good. It’s been over 4 years but we decided to wait no more so here is the code that was the basis of our work for our 2014 Cancer Research paper (as well as subsequent publications in Nature Scientific Reports in 2016 and the Bulletin of Mathematical Biology this year)

Etienne at Moffitt's 2018 Scientific Symposium

Not every year do we get to see ODEs in a presentation at the annual Moffitt Scientific Symposium so it was a refreshing change to see Etienne talk about experimental and mathematical integration in the quest to understand the role of macrophages in bone injury repair.

What do driver mutations do

Great talk today by Angelika Amon on aneuploudy and very interesting ideas about its potential impact on chromosomal instability and treatment resistance. Do we need to start looking at mutations differently?

The tumor environment and the tempo of somatic evolution

Our latest work looking at the pace of evolution and the role of the tumor's environment in driving that pace. We use an agent-based model and data from glioblastoma patients to show that certain microenvironments (at least in GBM) change the birth/death dynamics in hierarchically-organized tissues so that different sections of a tumor could have different paces of evolution

March for science 2018

Many of us in the Tampa Bay area (but certainly not as many as I was hoping) attended the 2018 edition of the march for science. As I wrote last year for the first edition of the march, we scientists need to be more involved in explaining to others what we do and why it has value.